ramid Blog

Arthramid (Polyacrylamide Hydrogel) for Equine Joints

Arthramid Vet, a 2.5% cross-linked polyacrylamide hydrogel (PAAG), has emerged as a groundbreaking treatment for managing osteoarthritis (OA) in horses. Unlike corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs), Arthramid integrates into the synovial membrane, improving joint lubrication and stabilising the joint capsule. This unique mechanism reduces inflammation, alleviates lameness, and enhances overall joint function. This guide delves into the science, application, and benefits of Arthramid therapy.

What Is Arthramid and How Does It Work? (Tnibar et al., 2017)

Arthramid is a non-biodegradable hydrogel composed of 2.5% polyacrylamide and 97.5% water. It integrates into the synovial membrane and forms a durable, gel-like matrix within the joint capsule.

Mechanisms of Action:

• Synovial Integration: Arthramid binds with synovial tissue, improving elasticity and reducing friction.
• Inflammation Reduction: Suppresses inflammatory cytokines like IL-1β and TNF-α.
• Joint Capsule Stabilization: Enhances joint capsule strength and reduces synovial effusion.
• Long-Lasting Effects: Provides durable biochemical and structural benefits.

When Is Arthramid Treatment Needed? (De Clifford et al., 2021)

Arthramid is recommended for:

• Chronic Osteoarthritis: Reducing inflammation and slowing disease progression.
• Joint Instability: Stabilizing and lubricating the joint capsule.
• Performance Horses: Enhancing mobility and reducing lameness in high-performance equine athletes.
• Post-Surgical Recovery: Supporting healing after joint-related surgeries.

How Effective Is Arthramid for Equine Joints? (De Clifford et al., 2021)

Key findings from clinical studies include:

• Improved Lameness Scores: Horses showed significant lameness reduction.
• Reduced Inflammation: Measurable decreases in IL-1β and TNF-α cytokines.
• Enhanced Joint Mobility: Long-lasting improvements in flexibility and range of motion.

Arthramid vs Traditional Joint Therapies (Bowkett-Pritchard, 2022)

Arthramid vs Corticosteroids:

• Arthramid: Long-term integration into synovial tissue.
• Corticosteroids: Provide temporary inflammation relief.

Arthramid vs Hyaluronic Acid (HA):

• Arthramid: Structural joint stabilization.
• HA: Enhances synovial fluid viscosity but lacks integration properties.

Administration of Arthramid (Reesink, 2020)

1. Joint Assessment: Veterinarians identify target joints through diagnostic imaging.
2. Sterile Injection: Arthramid is administered directly into the affected joint.
3. Rest Period: Horses typically require a short rest period before returning to exercise.
4. Follow-Up Monitoring: Veterinarians assess long-term improvements.

Advantages of Arthramid Therapy (Lowe et al., 2024)

• Long-Lasting Effects: Therapeutic benefits persist for over 12 months.
• Minimal Side Effects: Well-tolerated with low adverse reaction rates.
• Joint Stability: Enhanced synovial integrity.
• Inflammation Control: Significant reduction in cytokine activity.

Challenges with Arthramid Therapy (Janssen et al., 2012)

• High Cost: Arthramid is more expensive than traditional therapies.
• Variable Outcomes: Responses may vary depending on joint pathology.
• Limited Long-Term Data: Long-term follow-up studies are still emerging.

Supporting Arthramid with Nutrition

Optimal nutrition enhances Arthramid’s effectiveness:

• Omega-3 Fatty Acids: Combat chronic inflammation.
• Vitamin C and E: Provide antioxidant protection.
• Glucosamine and Chondroitin: Support cartilage health.

A tailored diet rich in these nutrients ensures maximum benefits from Arthramid therapy.

Future Directions for Arthramid Research (Sauer et al., 2024)

• Optimized Dosage Protocols: Determining ideal injection intervals.
• Combination Therapies: Exploring Arthramid with PRP and stem cells.
• Long-Term Studies: Assessing the durability of therapeutic effects.

Final Thoughts: Is Arthramid Right for Your Horse? (Bolwell et al., 2019)

Arthramid represents an innovative approach to equine joint therapy. Its ability to integrate with synovial tissue, provide lasting benefits, and reduce inflammation makes it a superior option for managing osteoarthritis and joint dysfunction in horses. While cost and long-term data remain considerations, Arthramid stands out as an effective and scientifically-backed choice for joint health..